NFκB activation in cutaneous lesions of leprosy is associated with development of multibacillary infection
Identifieur interne : 002795 ( Main/Exploration ); précédent : 002794; suivant : 002796NFκB activation in cutaneous lesions of leprosy is associated with development of multibacillary infection
Auteurs : Carlos G. Wambier [Brésil] ; Leandra Naira Z. Ramalho [Brésil] ; Marco Andrey C. Frade [Brésil] ; Norma T. Foss [Brésil]Source :
- Journal of Inflammation Research [ 1178-7031 ] ; 2014.
Abstract
Nuclear factor kappa B (NFκB) transcription factors play a central role in controlling the expression of genes involved in inflammatory reactions, proliferation, and survival of human cells. However, the in situ evaluation of NFκB activity in leprosy has not been completed previously. The aim of this study was to determine whether NFκB activity correlates with susceptibility or resistance to
The NFκB activation profile was evaluated in biopsies from skin lesions of 38 patients with the clinical and laboratory diagnosis of leprosy. NFκB activation was evaluated and quantified by Southwestern histochemistry, and its activation index (range, 0–4) was calculated according to the percentage of nuclear positivity by the histochemistry. Activation index >1 was considered representative of activation of NFκB.
Fifteen patients (39.5%) demonstrated activated NFκB. Multibacillary leprosy was associated with activated NFκB (54.5%,
These results indicate that NFκB activation could favor susceptibility and immunological instability to
Url:
DOI: 10.2147/JIR.S62562
PubMed: 25258550
PubMed Central: 4173660
Affiliations:
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Wambier</name><affiliation wicri:level="4"><nlm:aff id="af1-jir-7-133">Division of Dermatology, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Dermatology, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Ramalho, Leandra Naira Z" sort="Ramalho, Leandra Naira Z" uniqKey="Ramalho L" first="Leandra Naira Z" last="Ramalho">Leandra Naira Z. 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Wambier</name><affiliation wicri:level="4"><nlm:aff id="af1-jir-7-133">Division of Dermatology, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Dermatology, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Ramalho, Leandra Naira Z" sort="Ramalho, Leandra Naira Z" uniqKey="Ramalho L" first="Leandra Naira Z" last="Ramalho">Leandra Naira Z. Ramalho</name><affiliation wicri:level="4"><nlm:aff id="af2-jir-7-133">Department of Pathology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pathology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Frade, Marco Andrey C" sort="Frade, Marco Andrey C" uniqKey="Frade M" first="Marco Andrey C" last="Frade">Marco Andrey C. Frade</name><affiliation wicri:level="4"><nlm:aff id="af1-jir-7-133">Division of Dermatology, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Dermatology, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Foss, Norma T" sort="Foss, Norma T" uniqKey="Foss N" first="Norma T" last="Foss">Norma T. Foss</name><affiliation wicri:level="4"><nlm:aff id="af1-jir-7-133">Division of Dermatology, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Dermatology, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></analytic><series><title level="j">Journal of Inflammation Research</title><idno type="eISSN">1178-7031</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Nuclear factor kappa B (NFκB) transcription factors play a central role in controlling the expression of genes involved in inflammatory reactions, proliferation, and survival of human cells. However, the in situ evaluation of NFκB activity in leprosy has not been completed previously. The aim of this study was to determine whether NFκB activity correlates with susceptibility or resistance to <italic>Mycobacterium leprae</italic> infection in biopsies from skin lesions of 38 patients with the clinical and laboratory diagnosis of leprosy.</p></sec><sec><title>Methods</title><p>The NFκB activation profile was evaluated in biopsies from skin lesions of 38 patients with the clinical and laboratory diagnosis of leprosy. NFκB activation was evaluated and quantified by Southwestern histochemistry, and its activation index (range, 0–4) was calculated according to the percentage of nuclear positivity by the histochemistry. Activation index >1 was considered representative of activation of NFκB.</p></sec><sec><title>Results</title><p>Fifteen patients (39.5%) demonstrated activated NFκB. Multibacillary leprosy was associated with activated NFκB (54.5%, <italic>P</italic>=0.028). Borderline leprosy was most strongly associated with NFκB activation (80%), with an odds ratio of 32.7 (<italic>P</italic>=0.016). These clinical forms are characterized by increased susceptibility to <italic>M. leprae</italic> and by immunological instability. Activation of NFκB was absent in the granulomas in tuberculoid leprosy, which represents an effective inflammatory reaction pattern against <italic>M. leprae</italic>.</p></sec><sec><title>Conclusion</title><p>These results indicate that NFκB activation could favor susceptibility and immunological instability to <italic>M. leprae</italic> infection, potentially by the stimulation of phagocytosis and the regulation of apoptotic mechanisms of infected cells, leading to the proliferation of this intracellular bacillus. Further studies are needed to evaluate if inhibition of NFκB activation in multibacillary leprosy could favor resistance and an effective granulomatous immune response.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ridley, Ds" uniqKey="Ridley D">DS Ridley</name></author><author><name sortKey="Jopling, Wh" uniqKey="Jopling W">WH Jopling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnoldi, J" uniqKey="Arnoldi J">J Arnoldi</name></author><author><name sortKey="Gerdes, J" uniqKey="Gerdes J">J Gerdes</name></author><author><name sortKey="Flad, Hd" uniqKey="Flad H">HD Flad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kempe, S" uniqKey="Kempe S">S Kempe</name></author><author><name sortKey="Kestler, H" uniqKey="Kestler H">H Kestler</name></author><author><name sortKey="Lasar, A" uniqKey="Lasar A">A Lasar</name></author><author><name sortKey="Wirth, T" 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Wambier</name></region><name sortKey="Foss, Norma T" sort="Foss, Norma T" uniqKey="Foss N" first="Norma T" last="Foss">Norma T. Foss</name><name sortKey="Frade, Marco Andrey C" sort="Frade, Marco Andrey C" uniqKey="Frade M" first="Marco Andrey C" last="Frade">Marco Andrey C. Frade</name><name sortKey="Ramalho, Leandra Naira Z" sort="Ramalho, Leandra Naira Z" uniqKey="Ramalho L" first="Leandra Naira Z" last="Ramalho">Leandra Naira Z. Ramalho</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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